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首页> 外文OA文献 >Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine
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Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine

机译：在接种四价脑膜炎球菌荚膜多糖疫苗的补体缺陷型人群中预防脑膜炎球菌血清ACYW病

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Individuals with properdin, C3 or late complement component deficiency (LCCD) frequently develop meningococcal disease. Vaccination of these persons has been recommended, although reports on efficacy are scarce and not conclusive. We immunized 53 complement-deficient persons, of whom 19 had properdin deficiency, seven a C3 deficiency syndrome and 27 had LCCD with the tetravalent (ACYW) meningococcal capsular polysaccharide vaccine. Serological studies were performed in 43 of them. As controls 25 non-complement-deficient relatives of the complement-deficient vaccinees and 21 healthy non-related controls were vaccinated. Post-vaccination, complement-deficient individuals and controls developed a significant immunoglobulin-specific antibody response to capsular polysaccharides group A, C, Y, W135, but a great individual variation was noticed. Also, the proportion of vaccinees of the various vaccinated groups with a significant increase in bactericidal titre (assayed with heterologous complement) was similar. Opsonization of meningococci A and W135 with sera of the 20 LCCD individuals yielded in 11 (55%) and eight (40%) sera a significant increase of phagocytic activity after vaccination, respectively. Despite vaccination, four complement-deficient patients experienced six episodes of meningococcal disease in the 6 years post-vaccination. Four episodes were due to serogroup B, not included in the vaccine. Despite good response to serogroup Y upon vaccination, disease due to serogroup Y occurred in two C8β-deficient patients, 3.5 and 5 years post-vaccination. These results support the recommendation to vaccinate complement-deficient individuals and to revaccinate them every 3 years.
机译：备有备解素，C3或晚期补体成分缺乏症（LCCD）的人经常会出现脑膜炎球菌病。尽管很少有关于疗效的报告，但尚无定论，但建议对这些人进行疫苗接种。我们用四价（ACYW）脑膜炎球菌荚膜多糖疫苗免疫了53个补体缺陷型人群，其中19个有备解素缺乏症，7个C3缺乏综合症和27个LCCD。其中43人进行了血清学研究。作为对照，对25个补体缺陷疫苗的非补体缺陷亲戚和21个健康的非相关对照进行了疫苗接种。疫苗接种后，补体缺陷型个体和对照对荚膜多糖组A，C，Y，W135产生了显着的免疫球蛋白特异性抗体反应，但注意到个体差异很大。同样，具有不同的杀菌滴度（用异源补体测定）的各种接种组的疫苗接种者比例是相似的。用20个LCCD个体的血清对脑膜炎球菌A和W135进行调理，分别产生11（55％）和8（40％）血清，接种后吞噬活性显着增加。尽管进行了疫苗接种，但在疫苗接种后的6年中，有4名补体缺乏症患者发生了6次脑膜炎球菌疾病。四个发作是由于血清群B引起的，未包括在疫苗中。尽管接种后对Y血清群反应良好，但在接种后3.5年和5年，两名C8β缺陷型患者仍因Y血清群引起疾病。这些结果支持建议对补体缺陷型个体进行疫苗接种，并每3年重新接种一次。

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